Metal ions and synaptic transmission: Think zinc

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Commentary Metal ions and synaptic transmission: Think zinc

Zinc is abundant in the brain, having, after iron, the highest concentration among all transition metals. Most of this brain zinc ('90%) is bound up in metal–protein complexes, such as zinc-finger gene regulatory proteins, in which the zinc is used for enzymatic catalysis or for structural stability, and this tightly complexed portion of the zinc pool is essentially invisible to histochemical s...

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An Engineered Metal Sensor Tunes the Kinetics of Synaptic Transmission.

UNLABELLED The Ca(2+) sensor synaptotagmin-1 (syt-1) regulates neurotransmitter release by interacting with anionic phospholipids. Here we test the idea that the intrinsic kinetics of syt-membrane interactions determine, in part, the time course of synaptic transmission. To tune the kinetics of this interaction, we grafted structural elements from the slowest isoform, syt-7, onto the fastest is...

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Metal ions and carcinogenesis.

Metals are essential for the normal functioning of living organisms. Their uses in biological systems are varied, but are frequently associated with sites of critical protein function, such as zinc finger motifs and electron or oxygen carriers. These functions only require essential metals in minute amounts, hence they are termed trace metals. Other metals are, however, less beneficial, owing t...

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Effects of Zinc, Sodium and Potassium Metal Ions on Ammonium Fraction of Acid Phosphatase of Orange Fruit

Backgrounds and Aims: The purpose of this study was to examine the effects of potassium, sodium and zinc metal ions on ammonium sulfate fraction of acid phosphatase activity of orange fruit. Materials and Methods: Acid phosphatase was extracted and purified from orange fruit and then various samples as well as a control sample were prepared in vitro. In addition to substrates, ions of potass...

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application and construction of carbon paste modified electrodes developed for determination of metal ions in some real samples

ساخت الکترودهاِی اصلاح شده ِیکِی از چالشهاِی همِیشگِی در دانش شیمِی بوِیژه شیمِی تجزیه مِی باشد ،که با در نظر گرفتن سادگِی ساخت، کاربردی بودن و ارزان بودن روش مِی توان به باارزش بودن چنِین سنسورهاِی پِی برد.آنچه که در ادامه آورده شده به ساخت و کاربرد الکترودهاِی اصلاح شده با استفاده از نانو ذرات در اندازه گِیرِی ولتامترِی آهن وکادمِیم اشاره دارد. کار اول اختصاص دارد به ساخت الکترود خمِیر کربن اصلاح شده با لِیگاند داِ...

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ژورنال

عنوان ژورنال: Proceedings of the National Academy of Sciences

سال: 1997

ISSN: 0027-8424,1091-6490

DOI: 10.1073/pnas.94.25.13386